Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.64 |
| ▸ | MAOB | P27338 | 5/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 4/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761237 | 0.89 | PTGS1 (0.64) | PTGS2PTGS1MAOBMAOAGRM5 | |
| SCHEMBL8786024 | 0.85 | MAOB (0.51) | PTGS2PTGS1MAOBMAOAGRM5 | |
| SCHEMBL22967194 | 0.83 | MAOB (0.58) | PTGS2PTGS1MAOBMAOAGRM5 | |
| SCHEMBL1056332 | 0.79 | PTGS1 (1.00) | PTGS2PTGS1LTB4RLTB4R2HPGD | |
| SCHEMBL27581541 | 0.78 | PTGS1 (0.69) | PTGS2PTGS1FABP4AKR1C3AKR1C2 | |
| SCHEMBL10728119 | 0.78 | PTGS1 (0.44) | PTGS2PTGS1MAOBMAOAGRM5 | |
| SCHEMBL10594215 | 0.77 | MAOB (0.51) | MAOBMAOAGRM5HPGDNPC1 | |
| SCHEMBL1813122 | 0.75 | MAOB (0.56) | MAOBMAOAGRM5HPGDNPC1 | |
| SCHEMBL1533619 | 0.74 | MAOB (0.63) | MAOBMAOAGRM5HPGDNPC1 | |
| SCHEMBL9734614 | 0.73 | AKR1B1 (0.58) | PTGS2PTGS1NPC1ALDH1A1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035131-A1 | PYRAZOLINE COMPOUNDS | PFIZER INC | 2012-02-09 | — | — | US | disclosed |
| US-20100280016-A1 | PYRAZOLINE COMPOUNDS | PFIZER INC | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035131-A1 | PYRAZOLINE COMPOUNDS | F12, CYP3A7, ABCG2 | PTGS2 2848/4885PTGS1 1963/4885MAOB 134/4885 |
| US-20100280016-A1 | PYRAZOLINE COMPOUNDS | F12, CYP3A7, ABCG2 | PTGS2 2848/4885PTGS1 1963/4885MAOB 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.