Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PTGIR | P43119 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14451328 | 1.00 | ROCK2 (0.52) | ROCK2ROCK1HPGDLMNAPTGIR | |
| SCHEMBL5521781 | 1.00 | ROCK2 (0.52) | ROCK2ROCK1HPGDLMNAPTGIR | |
| SCHEMBL5518717 | 0.88 | AR (0.47) | ROCK2ROCK1ACACB | |
| SCHEMBL14451323 | 0.88 | AR (0.47) | ROCK2ROCK1ACACB | |
| SCHEMBL5518723 | 0.88 | AR (0.47) | ROCK2ROCK1ACACB | |
| SCHEMBL5525008 | 0.87 | ACACB (0.48) | ROCK2ROCK1ACACB | |
| SCHEMBL5525010 | 0.87 | ACACB (0.48) | ROCK2ROCK1ACACB | |
| SCHEMBL5722212 | 0.86 | HPGD (0.47) | ROCK2ROCK1HPGDLMNA | |
| SCHEMBL8284597 | 0.84 | HPGD (0.56) | HPGDLMNAPTGIR | |
| SCHEMBL5524760 | 0.81 | PTGIR (0.53) | LMNAPTGIRACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167452-A1 | Therapeutic amide derivatives | PFIZER, INC. | 2007-07-19 | — | — | US | disclosed |
| US-20070167452-A1 | Therapeutic amide derivatives | PFIZER, INC. | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167452-A1 | Therapeutic amide derivatives | GRIN1, GRIN2B, GRIN3A | ROCK2 4012/4885ROCK1 3844/4885HPGD 604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.