Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGIR | P43119 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285513 | 0.89 | POLB (0.53) | KMT2AMEN1POLBPTGIRNR1H4 | |
| SCHEMBL5513674 | 0.89 | PDE4A (0.54) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5513669 | 0.89 | PDE4A (0.54) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8283830 | 0.87 | CXCR3 (0.48) | KMT2AMEN1POLBCXCR3NR1H4 | |
| SCHEMBL5521806 | 0.86 | HDAC3 (0.51) | KMT2AMEN1CXCR3NR1H4 | |
| SCHEMBL5523321 | 0.86 | HDAC3 (0.51) | KMT2AMEN1CXCR3NR1H4 | |
| SCHEMBL5521812 | 0.86 | HDAC3 (0.51) | KMT2AMEN1CXCR3NR1H4 | |
| SCHEMBL5527587 | 0.85 | LMNA (0.48) | HPGDLMNAPDE4APDE4BPDE4C | |
| SCHEMBL5527593 | 0.85 | LMNA (0.48) | HPGDLMNAPDE4APDE4BPDE4C | |
| SCHEMBL5527590 | 0.85 | LMNA (0.48) | HPGDLMNAPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005080317-A2 | THERAPEUTIC AMIDE DERIVATIVES | PFIZER JAPAN, INC. (JP) | 2005-09-01 | — | — | WO | disclosed |