Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 9/20 | 0.36 |
| ▸ | HTR7 | P34969 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504389 | 0.91 | DRD2 (0.37) | DRD4DRD2HTR7HTR2AHTR1A | |
| SCHEMBL5509209 | 0.90 | DRD4 (0.38) | DRD4DRD2HTR7HTR2AHTR1A | |
| SCHEMBL5507695 | 0.90 | DRD4 (0.38) | DRD4DRD2HTR7HTR2AHTR1A | |
| SCHEMBL5509702 | 0.82 | DRD2 (0.37) | DRD4DRD2HTR2AHTR1ADRD3 | |
| SCHEMBL5509253 | 0.81 | DRD2 (0.44) | DRD4DRD2HTR7HTR2AHTR1A | |
| SCHEMBL5532866 | 0.81 | DRD4 (0.38) | DRD4DRD2HTR7HTR2AHTR1A | |
| SCHEMBL2783359 | 0.81 | DRD2 (0.50) | DRD4DRD2HTR7HTR2AHTR1A | |
| SCHEMBL2782893 | 0.81 | DRD2 (0.47) | DRD4DRD2HTR7HTR2AHTR1A | |
| SCHEMBL5502304 | 0.80 | DRD2 (0.38) | DRD4DRD2HTR1ALMNAGAA | |
| SCHEMBL3105655 | 0.80 | DRD4 (0.41) | DRD4DRD2HTR7HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | claimed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |