Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.37 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 6/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503520 | 0.91 | DRD2 (0.40) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL5502634 | 0.85 | DRD2 (0.45) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL5505574 | 0.84 | P2RX7 (0.36) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL5532366 | 0.84 | P2RX7 (0.36) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL2784187 | 0.83 | DRD2 (0.45) | DRD2HTR2AHRH1HTR1ADRD4 | |
| SCHEMBL5503773 | 0.82 | DRD2 (0.37) | DRD2HTR2AHRH1HTR1ADRD4 | |
| SCHEMBL5522908 | 0.82 | DRD4 (0.38) | DRD2HTR2AHRH1HTR1ADRD4 | |
| SCHEMBL2784938 | 0.81 | MAPT (0.44) | DRD2HTR2ADRD4DRD3HSD17B10 | |
| SCHEMBL5505305 | 0.81 | DRD2 (0.37) | DRD2HTR2AHRH1HTR1ADRD4 | |
| SCHEMBL5504389 | 0.81 | DRD2 (0.37) | DRD2HTR2AHRH1HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | claimed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |