Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.59 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | WDR5 | P61964 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26926142 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HPGDUSP2ERCC1ERCC4 | |
| SCHEMBL14724835 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HPGDUSP2ERCC1ERCC4 | |
| SCHEMBL13039162 | 0.83 | SMN1; SMN2 (0.64) | ALDH1A1HPGDUSP2ERCC1ERCC4 | |
| SCHEMBL507837 | 0.82 | ALDH1A1 (0.90) | ALDH1A1HPGDUSP2ERCC1ERCC4 | |
| SCHEMBL17048526 | 0.81 | ALDH1A1 (0.63) | ALDH1A1HPGDUSP2ERCC1ERCC4 | |
| SCHEMBL25976163 | 0.81 | USP2 (0.63) | ALDH1A1HPGDUSP2ERCC1ERCC4 | |
| SCHEMBL6244724 | 0.80 | ALDH1A1 (0.93) | ALDH1A1HPGDUSP2ERCC1ERCC4 | |
| SCHEMBL12993457 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HPGDUSP2ERCC1ERCC4 | |
| SCHEMBL5530350 | 0.80 | ALDH1A1 (0.72) | ALDH1A1KMT2ACYP3A4CYP2C9HSD17B10 | |
| SCHEMBL5526975 | 0.80 | KDM4E (0.65) | ALDH1A1HPGDUSP2ERCC1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | ALDH1A1 2069/4885HPGD 3176/4885USP2 3213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.