Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 11/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030503 | 1.00 | ADRA2A (0.51) | ADRA2AMCHR1NPY5RMAPTHTR1A | |
| SCHEMBL4531832 | 0.90 | MCHR1 (0.53) | ADRA2AMCHR1NPY5RMAPTHTR1A | |
| SCHEMBL4531828 | 0.90 | MCHR1 (0.53) | ADRA2AMCHR1NPY5RMAPTHTR1A | |
| SCHEMBL5518649 | 0.87 | MCHR1 (0.54) | ADRA2AMCHR1NPY5RMAPTHTR1A | |
| SCHEMBL5518644 | 0.87 | MCHR1 (0.54) | ADRA2AMCHR1NPY5RMAPTHTR1A | |
| SCHEMBL5522648 | 0.84 | MCHR1 (0.53) | ADRA2AMCHR1NPY5RHTR1AADRA1A | |
| SCHEMBL5522652 | 0.84 | MCHR1 (0.53) | ADRA2AMCHR1NPY5RHTR1AADRA1A | |
| SCHEMBL5522036 | 0.83 | MCHR1 (0.53) | ADRA2AMCHR1NPY5RMAPTHTR1A | |
| SCHEMBL5522041 | 0.83 | MCHR1 (0.53) | ADRA2AMCHR1NPY5RMAPTHTR1A | |
| SCHEMBL13796281 | 0.83 | MCHR1 (0.63) | ADRA2AMCHR1NPY5RHTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | claimed |
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | ADRA2A 103/4885MCHR1 1/4885NPY5R 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.