Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.61 |
| ▸ | PTPRC | P08575 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 2/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926086 | 0.88 | ALDH1A1 (0.59) | S100A4PTPRCCYP1A2MAPK1ALDH1A1 | |
| SCHEMBL9769393 | 0.84 | ALDH1A1 (0.59) | PTPRCCYP1A2MAPK1ALDH1A1APP | |
| SCHEMBL39700 | 0.82 | S100A4 (0.90) | S100A4PTPRCBCL2MCL1CYP1A2 | |
| SCHEMBL29390614 | 0.82 | S100A4 (0.90) | S100A4PTPRCBCL2MCL1CYP1A2 | |
| SCHEMBL4129142 | 0.81 | ALDH1A1 (0.59) | S100A4PTPRCBCL2MCL1CYP1A2 | |
| SCHEMBL9514250 | 0.80 | ALDH1A1 (0.59) | CYP1A2MAPK1ALDH1A1APPL3MBTL1 | |
| SCHEMBL3091326 | 0.79 | ALDH1A1 (0.61) | PTPRCBCL2MCL1CYP1A2MAPK1 | |
| SCHEMBL19767754 | 0.78 | S100A4 (0.81) | S100A4PTPRCBCL2MCL1CYP1A2 | |
| SCHEMBL20313056 | 0.77 | MAPK1 (0.56) | S100A4PTPRCBCL2MCL1CYP1A2 | |
| SCHEMBL29514452 | 0.77 | S100A4 (1.00) | S100A4PTPRCBCL2MCL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| US-20050271584-A1 | Biphenyls and fluorenes as imaging agents in alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2005-12-08 | — | — | US | disclosed |
| US-20050214222-A1 | In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2005-09-29 | — | — | US | disclosed |
| EP-1553985-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | The Trustees of The University of Pennsylvania (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004032975-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | S100A4 94/4885PTPRC 3309/4885BCL2 321/4885 |
| US-20050271584-A1 | Biphenyls and fluorenes as imaging agents in alzheimer's disease | APP, BACE2, BACE1 | S100A4 288/4885PTPRC 3961/4885BCL2 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.