Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26023533 | 0.81 | PGR (0.44) | PGRGPR3HTR2BHTR7KMT2A | |
| SCHEMBL1033749 | 0.76 | HTR2B (0.43) | PGRHTR2BHTR7KMT2AALDH1A1 | |
| SCHEMBL18385982 | 0.75 | HTR2B (0.50) | PGRGPR3HTR2BHTR7KMT2A | |
| SCHEMBL5526151 | 0.73 | PDK2 (0.50) | PGRGPR3HTR2BHTR7KMT2A | |
| SCHEMBL20082694 | 0.71 | CYP1A2 (0.53) | PGRHTR2BHTR7KMT2AALDH1A1 | |
| SCHEMBL22336275 | 0.71 | HTR2B (0.47) | PGRHTR2BHTR7KMT2AALDH1A1 | |
| SCHEMBL30441120 | 0.71 | HTR2B (0.47) | PGRHTR2BHTR7KMT2AALDH1A1 | |
| SCHEMBL216862 | 0.71 | MAOA (0.52) | PGRGPR3HTR2BHTR7KMT2A | |
| SCHEMBL29376368 | 0.71 | MAOA (0.52) | PGRGPR3HTR2BHTR7KMT2A | |
| SCHEMBL29884836 | 0.71 | MAOA (0.52) | PGRGPR3HTR2BHTR7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| US-20050271584-A1 | Biphenyls and fluorenes as imaging agents in alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2005-12-08 | — | — | US | disclosed |
| US-20050214222-A1 | In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2005-09-29 | — | — | US | disclosed |
| EP-1553985-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | The Trustees of The University of Pennsylvania (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004032975-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | PGR 4308/4885GPR3 3746/4885HTR2B 3641/4885 |
| US-20050271584-A1 | Biphenyls and fluorenes as imaging agents in alzheimer's disease | APP, BACE2, BACE1 | PGR 3835/4885GPR3 1065/4885HTR2B 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.