Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28009767 | 0.92 | ALDH1A1 (0.49) | ALDH1A1KMT2ASMN1; SMN2LMNAPOLB | |
| SCHEMBL6627416 | 0.86 | ITGB1 (0.47) | ALDH1A1KMT2AMMP1ITGB1ITGA4 | |
| SCHEMBL8586015 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KMT2AMMP1ITGB1ITGA4 | |
| SCHEMBL6626906 | 0.84 | ALDH1A1 (0.48) | ALDH1A1KMT2AMMP1ITGB1ITGA4 | |
| SCHEMBL18759154 | 0.84 | ITGB1 (0.46) | ALDH1A1KMT2AMMP1ITGB1ITGA4 | |
| SCHEMBL5530347 | 0.83 | MEN1 (0.50) | KMT2AITGB1ITGA4MAPTNPC1 | |
| SCHEMBL4886593 | 0.83 | ITGB1 (0.51) | ALDH1A1KMT2AMMP1ITGB1ITGA4 | |
| SCHEMBL5520748 | 0.81 | CYP3A4 (0.47) | LMNAEPHX2CYP3A4CYP2C19 | |
| SCHEMBL4600032 | 0.81 | EPHX1 (0.41) | ALDH1A1TSHRCYP3A4 | |
| SCHEMBL6627953 | 0.79 | ALDH1A1 (0.70) | ALDH1A1KMT2AMAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | ALDH1A1 2069/4885KMT2A 792/4885MMP1 4706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.