Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15453396 | 0.92 | ALDH1A1 (0.81) | ALDH1A1SMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL26097960 | 0.92 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2NPC1RAB9AHDAC6 | |
| SCHEMBL26102262 | 0.91 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL23747460 | 0.90 | SMN1; SMN2 (0.65) | ALDH1A1SMN1; SMN2NPC1RAB9AHDAC6 | |
| SCHEMBL26100647 | 0.88 | SMN1; SMN2 (0.67) | ALDH1A1SMN1; SMN2NPC1RAB9AHDAC6 | |
| SCHEMBL26102668 | 0.88 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL17182848 | 0.87 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL17182851 | 0.87 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL17182903 | 0.87 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL13745650 | 0.86 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2NPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | ALDH1A1 2069/4885SMN1; SMN2 1509/4885NPC1 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.