Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5524484 | 1.00 | HDAC8 (0.58) | HDAC8MAP3K7TAB1BACE1GSK3B | |
| SCHEMBL1549368 | 0.89 | MEN1 (0.56) | HDAC8PTGER3PTGDRMEN1HSP90AA1 | |
| SCHEMBL1549366 | 0.89 | MEN1 (0.56) | HDAC8PTGER3PTGDRMEN1HSP90AA1 | |
| SCHEMBL9199951 | 0.89 | HDAC8 (0.59) | HDAC8MAP3K7TAB1BACE1GSK3B | |
| SCHEMBL4839242 | 0.88 | ALDH1A1 (0.61) | HDAC8BACE1GSK3BPTGER3PTGDR | |
| SCHEMBL4839224 | 0.88 | ALDH1A1 (0.61) | HDAC8BACE1GSK3BPTGER3PTGDR | |
| SCHEMBL18559977 | 0.86 | HDAC8 (0.69) | HDAC8BACE1GSK3BMEN1KMT2A | |
| SCHEMBL865802 | 0.86 | HDAC8 (0.57) | HDAC8MAP3K7TAB1BACE1GSK3B | |
| SCHEMBL865803 | 0.86 | HDAC8 (0.57) | HDAC8MAP3K7TAB1BACE1GSK3B | |
| SCHEMBL1723809 | 0.86 | HDAC8 (0.57) | HDAC8MAP3K7TAB1BACE1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203155-A1 | Compounds And Compositions As Ppar Modulators | IRM LLC (BM) | 2007-08-30 | — | — | US | disclosed |
| EP-1748993-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2007-02-07 | — | — | EP | disclosed |
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005116000-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203155-A1 | Compounds And Compositions As Ppar Modulators | PPARG, PPARA, PPARD | HDAC8 278/4885MAP3K7 1767/4885TAB1 2042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.