Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL865803 | 1.00 | HDAC8 (0.57) | HDAC8MAP3K7TAB1BACE1GSK3B | |
| SCHEMBL865802 | 1.00 | HDAC8 (0.57) | HDAC8MAP3K7TAB1BACE1GSK3B | |
| SCHEMBL9199951 | 0.88 | HDAC8 (0.59) | HDAC8MAP3K7TAB1BACE1GSK3B | |
| SCHEMBL865293 | 0.87 | ALDH1A1 (0.61) | HDAC8BACE1GSK3BPTGER3PTGDR | |
| SCHEMBL2781980 | 0.87 | ALDH1A1 (0.61) | HDAC8BACE1GSK3BPTGER3PTGDR | |
| SCHEMBL865294 | 0.87 | ALDH1A1 (0.61) | HDAC8BACE1GSK3BPTGER3PTGDR | |
| SCHEMBL5524486 | 0.86 | HDAC8 (0.58) | HDAC8MAP3K7TAB1BACE1GSK3B | |
| SCHEMBL5524484 | 0.86 | HDAC8 (0.58) | HDAC8MAP3K7TAB1BACE1GSK3B | |
| SCHEMBL18559977 | 0.85 | HDAC8 (0.69) | HDAC8BACE1GSK3BKDM4EALDH1A1 | |
| SCHEMBL8070061 | 0.81 | HDAC8 (0.50) | HDAC8KDM4EALDH1A1MAPTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406247-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103333-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |