SCHEMBL5524904

SCHEMBL5524904

CSc1nc2ccccc2c(=O)n1-c1c(F)cccc1F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PDE7A Q13946 12/20 1.00
PDE7B Q9NP56 3/20 1.00
PDE4A P27815 2/20 1.00
PDE4B Q07343 2/20 1.00
PDE4C Q08493 2/20 1.00
PDE4D Q08499 2/20 1.00
LMNA P02545 2/20 0.57
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
ATM Q13315 1/20 0.52
L3MBTL1 Q9Y468 2/20 0.46
GLA P06280 1/20 0.46
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18239989 0.85 PDE7A (1.00) PDE7APDE7BPDE4APDE4BPDE4C
SCHEMBL291137 0.83 PDE7A (1.00) PDE7APDE7BPDE4APDE4BPDE4C
SCHEMBL30837930 0.83 PDE7A (1.00) PDE7APDE7BPDE4APDE4BPDE4C
SCHEMBL290341 0.83 PDE7A (0.71) PDE7APDE7BPDE4APDE4BPDE4C
SCHEMBL29832352 0.81 PDE7A (1.00) PDE7APDE7BPDE4APDE4BPDE4C
SCHEMBL289913 0.81 PDE7A (1.00) PDE7APDE7BPDE4APDE4BPDE4C
SCHEMBL19487245 0.81 LMNA (0.77) PDE7APDE7BPDE4APDE4BPDE4C
SCHEMBL19015256 0.78 PDE7A (0.67) PDE7APDE7BPDE4APDE4BPDE4C
SCHEMBL9972171 0.76 LMNA (0.74) PDE7APDE7BPDE4APDE4BPDE4C
SCHEMBL5030398 0.76 MAPT (0.67) PDE7APDE7BPDE4APDE4BPDE4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4197318-B1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION UNIV FREIBURG ALBERT LUDWIGS (DE) 2025-11-19 EP claimed
US-20250057097-A1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) 2025-02-20 US claimed
WO-2023110673-A1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) 2023-06-22 WO claimed
EP-4197318-A1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION Albert-Ludwigs-Universität Freiburg (DE) 2023-06-21 EP claimed
EP-4197318-B1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION UNIV FREIBURG ALBERT LUDWIGS (DE) 2025-11-19 EP disclosed
US-20250057097-A1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) 2025-02-20 US disclosed
WO-2023110673-A1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) 2023-06-22 WO disclosed
WO-2023110673-A1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) 2023-06-22 WO disclosed
EP-4197318-A1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION Albert-Ludwigs-Universität Freiburg (DE) 2023-06-21 EP disclosed
EP-4197318-A1 PHOSPHODIESTERASES INHIBITORS TO PROMOTE IN VITRO PLANT CELL REPROGRAMMING TOWARDS PLANT EMBRYOGENESIS OR MICROCALLUS FORMATION Albert-Ludwigs-Universität Freiburg (DE) 2023-06-21 EP disclosed
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
US-11207275-B2 Treatment of addiction and impulse-control disorders using PDE7 inhibitors OMEROS CORPORATION (US) 2021-12-28 US disclosed
US-8637528-B2 Use of PDE7 inhibitors for the treatment of movement disorders OMEROS CORPORATION (US) 2014-01-28 US disclosed
US-8637528-B2 Use of PDE7 inhibitors for the treatment of movement disorders OMEROS CORPORATION (US) 2014-01-28 US disclosed
US-20130267502-A1 Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors OMEROS CORPORATION 2013-10-10 US disclosed
US-20130267502-A1 Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors OMEROS CORPORATION 2013-10-10 US disclosed
US-20120115849-A1 Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors OMEROS CORPORATION 2012-05-10 US disclosed
US-20120115849-A1 Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors OMEROS CORPORATION 2012-05-10 US disclosed
US-20100113486-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS OMEROS CORPORATION (US) 2010-05-06 US disclosed
US-20100113486-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS OMEROS CORPORATION (US) 2010-05-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120115849-A1 Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors PDE7B, PDE4C, PDE4A PDE7A 10/4885PDE7B 1/4885PDE4A 3/4885
US-11207275-B2 Treatment of addiction and impulse-control disorders using PDE7 inhibitors PDE7B, PDE4C, PDE4A PDE7A 10/4885PDE7B 1/4885PDE4A 3/4885
US-20130267502-A1 Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors PDE7B, PDE4C, PDE4A PDE7A 10/4885PDE7B 1/4885PDE4A 3/4885
US-20100113486-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS PARK7, PDE7B, PDE7A PDE7A 3/4885PDE7B 2/4885PDE4A 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.