Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.75 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.75 |
| ▸ | SHBG | P04278 | 5/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | STS | P08842 | 4/20 | 0.75 |
| ▸ | PGR | P06401 | 4/20 | 0.75 |
| ▸ | AR | P10275 | 4/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.75 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.75 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.75 |
| ▸ | SNCA | P37840 | 3/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.75 |
| ▸ | HTR2B | P41595 | 3/20 | 0.75 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.75 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1236350 | 1.00 | ESR1 (0.75) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL14924234 | 1.00 | ESR1 (0.75) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL12888972 | 1.00 | ESR1 (0.75) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL13655771 | 0.87 | ESR1 (0.75) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL13752801 | 0.87 | ESR1 (0.75) | ESR1ESR2SHBGHSD17B10LMNA | |
| Estrone SCHEMBL23529835 | 0.86 | CYP19A1 (0.95) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL17068938 | 0.86 | STS (0.56) | ESR1ESR2SHBGHSD17B10LMNA | |
| Estrone SCHEMBL157262 | 0.86 | CYP19A1 (1.00) | ESR1ESR2SHBGHSD17B10LMNA | |
| Estrone SCHEMBL7831317 | 0.86 | CYP19A1 (1.00) | ESR1ESR2SHBGHSD17B10LMNA | |
| Estrone SCHEMBL12054811 | 0.86 | CYP19A1 (1.00) | ESR1ESR2SHBGHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715517-B1 | ESTRENE STEROIDS AS NEUROCHEMICAL INITIATORS OF CHANGE IN HUMAN HYPOTHALAMIC FUNCTION AND RELATED PHARMACEUTICAL COMPOSITIONS | PHERIN PHARM INC (US) | 2003-11-05 | — | — | EP | claimed |
| EP-0847399-A1 | NOVEL ESTROGENS | Astra Aktiebolag (SE) | 1998-06-17 | — | — | EP | claimed |
| WO-1997008188-A1 | NOVEL ESTROGENS | ASTRA AKTIEBOLAG (SE) | 1997-03-06 | — | — | WO | claimed |
| JP-1197438-A | — | — | None | — | — | JP | disclosed |
| US-20070142345-A1 | Steroids for cancer treatment | INNOVENTUS PROJECT AB (SE) | 2007-06-21 | — | — | US | disclosed |
| EP-1716166-A2 | 17-METHYLENE- OR 17-SPIRO-CYCLOPROPANE 7-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE DERIVATIVES WITH ANTI-ESTROGENIC ACTIVITY | Innoventus Project AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005077968-A2 | 17-METHYLENE-OR 17 - SPIRO - CYCLOPROPANE 7 - SUBSTITUTED ESTRA - 1, 3, 5 (10) - TRIENE DERIVATIVES WITH ANTI - ESTROGENIC ACTIVITY | INNOVENTUS PROJECT AB (SE) | 2005-08-25 | — | — | WO | disclosed |
| EP-0891188-A4 | STEROIDS AS NEUROCHEMICAL INITIATORS OF CHANGE IN HUMAN BLOOD LEVELS OF LH OR FSH | PHERIN PHARM INC (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-0914165-A4 | STEROIDS AS NEUROCHEMICAL STIMULATORS OF THE VNO TO ALLEVIATE SYMPTOMS OF PMS AND ANXIETY | PHERIN PHARM INC (US) | 2004-01-21 | — | — | EP | disclosed |
| US-6352980-B1 | ADMINISTERING BY SPRAYING IN NOSE | PHERIN PHARMACEUTICALS, INC. | 2002-03-05 | — | — | US | disclosed |
| US-6331534-B1 | ADMINISTERING EFFECTIVE AMOUNT OF STEROID WITHIN NASAL PASSAGE OF INDIVIDUAL SUCH THAT IT BINDS SPECIFICALLY TO RECEPTORS ON SURFACE OF NASAL NEUROEPITHELIAL CELLS IN VOMERONASAL ORGAN | PHERIN PHARMACEUTICALS, INC. | 2001-12-18 | — | — | US | disclosed |
| WO-1997036596-A9 | STEROIDS AS NEUROCHEMICAL INITIATORS OF CHANGE IN HUMAN BLOOD LEVELS OF LH OR FSH | — | 1997-12-04 | — | — | WO | disclosed |
| WO-1997036596-A1 | STEROIDS AS NEUROCHEMICAL INITIATORS OF CHANGE IN HUMAN BLOOD LEVELS OF LH OR FSH | PHERIN PHARMACEUTICALS, INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| EP-0783513-A1 | NOVEL ESTRENES FOR INDUCING HYPOTHALAMIC EFFECTS | PHERIN CORPORATION (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5633392-A | STIMULANTS FOR AUTONOMIC NERVOUS SYSTEM; NOSE SPRAYING | PHERIN CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| WO-1997008188-A1 | NOVEL ESTROGENS | ASTRA AKTIEBOLAG (SE) | 1997-03-06 | — | — | WO | disclosed |
| WO-1996010032-A1 | NOVEL ESTRENES FOR INDUCING HYPOTHALAMIC EFFECTS | PHERIN CORPORATION (US) | 1996-04-04 | — | — | WO | disclosed |
| US-4977147-A | CONTRACEPTIVES, ANTITUMOR AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-12-11 | — | — | US | disclosed |
| JP-H01197438-A | MEDICINAL PREPARATION FOR TREATING MENOPAUSAL DISORDER AND HORMONE-DEPENDENT TUMOR AND AS CONTRACEPTIVE, AND PRODUCTION OF THE MEDICINAL PREPARATION | SCHERING AG | 1989-08-09 | — | — | JP | disclosed |
| EP-0320437-A2 | 17-Methylene and 17-ethylidene estratrienes having an oestrogenic activity | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142345-A1 | Steroids for cancer treatment | HSD17B11, ESRRB, ESRRA | ESR1 9/4885ESR2 7/4885SHBG 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.