Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 5/20 | 0.33 |
| ▸ | SI | P14410 | 5/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.33 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5523932 | 0.84 | ACHE (0.43) | ACHESENP1MGAMGAASI | |
| SCHEMBL6058489 | 0.78 | ACHE (0.38) | ACHESENP1MGAMGAASI | |
| SCHEMBL6059195 | 0.76 | USP7 (0.37) | ACHESENP1MMP2MMP3ESR1 | |
| SCHEMBL6059279 | 0.76 | ESR1 (0.34) | ACHESENP1MGAMGAASI | |
| Phenol SCHEMBL7160743 | 0.73 | MMP3 (0.37) | ACHESENP1MGAMGAASI | |
| SCHEMBL6704388 | 0.72 | ESR1 (0.47) | MGAMGAASIMGAM2ESRRG | |
| SCHEMBL5531079 | 0.71 | VHL (0.37) | ACHESENP1MGAMGAASI | |
| SCHEMBL5528639 | 0.71 | BACE1 (0.38) | GAAESR1 | |
| SCHEMBL23665864 | 0.70 | SLC6A2 (0.37) | APPRXRARXRBCCR5 | |
| SCHEMBL28231446 | 0.70 | APP (0.47) | SENP1MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249706-A1 | USE OF CERTAIN BIPHENYL COMPOUNDS FOR PROTECTION OF NEURONS AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) | AVENTIS PHARMACEUTICALS INC. (US) | 2007-10-25 | — | — | US | claimed |
| US-20070249706-A1 | USE OF CERTAIN BIPHENYL COMPOUNDS FOR PROTECTION OF NEURONS AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) | AVENTIS PHARMACEUTICALS INC. (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249706-A1 | USE OF CERTAIN BIPHENYL COMPOUNDS FOR PROTECTION OF NEURONS AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) | AVENTIS PHARMACEUTICALS INC. (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249706-A1 | USE OF CERTAIN BIPHENYL COMPOUNDS FOR PROTECTION OF NEURONS AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) | AVENTIS PHARMACEUTICALS INC. (US) | 2007-10-25 | — | — | US | disclosed |
| EP-1833472-A2 | USE OF CERTAIN BIPHENYL COMPOUNDS FOR PROTECTION OF NEURONS AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) | Aventis Pharmaceuticals Inc. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006073726-A2 | USE OF CERTAIN BIPHENYL COMPOUNDS FOR PROTECTION OF NEURONS AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) | AVENTIS PHARMACEUTICALS INC. (US) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249706-A1 | USE OF CERTAIN BIPHENYL COMPOUNDS FOR PROTECTION OF NEURONS AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) | MSR1, GMFG, PMP22 | ACHE 245/4885SENP1 1622/4885MGAM 4580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.