Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 16/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5525511 | 1.00 | OPRD1 (0.76) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5977141 | 1.00 | OPRD1 (0.76) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5975417 | 0.94 | OPRD1 (0.77) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5976396 | 0.94 | OPRD1 (0.72) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5975409 | 0.94 | OPRD1 (0.72) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5975405 | 0.94 | OPRD1 (0.72) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL14343504 | 0.93 | OPRD1 (0.73) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5522686 | 0.92 | OPRD1 (0.65) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5522677 | 0.92 | OPRD1 (0.65) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5521740 | 0.91 | OPRD1 (0.74) | OPRD1OPRM1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293502-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2007-12-20 | — | — | US | claimed |
| EP-1706393-A1 | DIARYLMETHYL PIPERAZINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-10-04 | — | — | EP | claimed |
| WO-2005066148-A1 | DIARYLMETHYL PIPERAZINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | claimed |
| US-20070293502-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293502-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | OPRL1, OPRM1, PTGER3 | OPRD1 10/4885OPRM1 2/4885OPRK1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.