SCHEMBL5526652

SCHEMBL5526652

O=C(O)CCNC(=O)c1noc2c1CN(C(=O)Nc1cc(F)ccc1F)CC2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.44
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
POLB P06746 2/20 0.44
ALOX15 P16050 1/20 0.44
HTT P42858 1/20 0.44
MCL1 Q07820 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
HSP90AA1 P07900 7/20 0.44
ALDH1A1 P00352 4/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2582941 0.88 HSP90AA1 (0.44) SMN1; SMN2NPC1RAB9APOLBALOX15
SCHEMBL5526492 0.72 ALDH1A1 (0.46) SMN1; SMN2NPC1RAB9AL3MBTL1HSP90AA1
SCHEMBL2584725 0.68 HSP90AA1 (0.48) SMN1; SMN2NPC1RAB9AALOX15HSD17B10
SCHEMBL2587840 0.68 RAB9A (0.53) SMN1; SMN2NPC1RAB9AHSD17B10HSP90AA1
SCHEMBL2582945 0.68 HSP90AA1 (0.44) NPC1HTTHSP90AA1ALDH1A1HDAC3
SCHEMBL22624651 0.67 HSP90AA1 (0.41) SMN1; SMN2NPC1RAB9APOLBALOX15
SCHEMBL22616254 0.67 SMN1; SMN2 (0.41) SMN1; SMN2NPC1RAB9APOLBHSD17B10
SCHEMBL22616252 0.67 SMN1; SMN2 (0.41) SMN1; SMN2NPC1RAB9APOLBHSD17B10
SCHEMBL2586908 0.67 ALDH1A1 (0.58) SMN1; SMN2NPC1RAB9AHTTHSD17B10
SCHEMBL22624779 0.66 NPC1 (0.45) SMN1; SMN2NPC1RAB9APOLBALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP disclosed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO disclosed