Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5528074 | 0.93 | MAPT (0.61) | MAPTLMNAL3MBTL1SGMS2SMN1; SMN2 | |
| SCHEMBL5749408 | 0.91 | LMNA (0.57) | MAPTLMNAL3MBTL1SGMS2SMN1; SMN2 | |
| SCHEMBL6424689 | 0.88 | LMNA (0.55) | MAPTLMNAL3MBTL1SGMS2SMN1; SMN2 | |
| SCHEMBL5520252 | 0.86 | LMNA (0.54) | MAPTLMNAL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6372444 | 0.86 | LMNA (0.60) | MAPTLMNAL3MBTL1SGMS2SMN1; SMN2 | |
| SCHEMBL5530865 | 0.85 | LMNA (0.59) | MAPTLMNAL3MBTL1SGMS2SMN1; SMN2 | |
| SCHEMBL5519164 | 0.84 | LMNA (0.56) | MAPTLMNAL3MBTL1SGMS2SMN1; SMN2 | |
| SCHEMBL5519289 | 0.84 | LMNA (0.58) | MAPTLMNAL3MBTL1SGMS2SMN1; SMN2 | |
| SCHEMBL6373350 | 0.82 | LMNA (0.53) | MAPTLMNAL3MBTL1SGMS2SMN1; SMN2 | |
| SCHEMBL5519519 | 0.82 | LMNA (0.58) | MAPTLMNAL3MBTL1SGMS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155744-A1 | N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4- carboxamide compounds useful as hiv integrase inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P, ANGELETTI S.P.A. (IT) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155744-A1 | N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4- carboxamide compounds useful as hiv integrase inhibitors | DUT, NQO2, TYMP | MAPT 3791/4885LMNA 2213/4885L3MBTL1 2326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.