Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.41 |
| ▸ | EDNRB | P24530 | 4/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774354 | 0.89 | EDNRA (0.44) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL5789921 | 0.87 | EDNRA (0.44) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL5532211 | 0.87 | EDNRA (0.44) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL4773395 | 0.85 | AGTR1 (0.47) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL4764949 | 0.85 | EDNRA (0.45) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL4764477 | 0.85 | AGTR1 (0.45) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL4770992 | 0.84 | EDNRA (0.43) | EDNRAEDNRB | |
| SCHEMBL4770983 | 0.84 | EDNRA (0.43) | EDNRAEDNRB | |
| SCHEMBL5534068 | 0.84 | AGTR1 (0.41) | EDNRAEDNRBAGTR1ABCB11GP6 | |
| SCHEMBL5520706 | 0.84 | EDNRA (0.42) | EDNRAEDNRBAGTR1ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | claimed |
| EP-1237888-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001044239-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2001-06-21 | — | — | WO | claimed |