Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | CASP1 | P29466 | 5/20 | 1.00 |
| ▸ | CASP7 | P55210 | 5/20 | 1.00 |
| ▸ | POLB | P06746 | 5/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | NPC1 | O15118 | 3/20 | 0.77 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | GAA | P10253 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | RAD52 | P43351 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527836 | 0.91 | TSHR (0.83) | TSHRMAPTCASP1CASP7POLB | |
| SCHEMBL16084877 | 0.88 | TSHR (0.78) | TSHRMAPTCASP1CASP7POLB | |
| SCHEMBL5524713 | 0.87 | MAPT (1.00) | TSHRMAPTCASP1CASP7POLB | |
| SCHEMBL15289657 | 0.84 | TSHR (0.72) | TSHRMAPTCASP1CASP7POLB | |
| SCHEMBL9706282 | 0.84 | TSHR (0.72) | TSHRMAPTCASP1CASP7POLB | |
| SCHEMBL13889180 | 0.84 | POLB (1.00) | TSHRMAPTCASP1CASP7POLB | |
| SCHEMBL9706276 | 0.83 | POLB (0.75) | TSHRMAPTCASP1CASP7POLB | |
| Hydrochloric Acid SCHEMBL9436868 | 0.83 | TSHR (0.70) | TSHRMAPTCASP1CASP7POLB | |
| SCHEMBL13165175 | 0.83 | TSHR (0.70) | TSHRMAPTCASP1CASP7POLB | |
| SCHEMBL9706178 | 0.81 | TSHR (0.68) | TSHRMAPTCASP1CASP7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160158247-A1 | Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors | OMEROS CORPORATION | 2016-06-09 | — | — | US | disclosed |
| US-20160015715-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | OMEROS CORPORATION | 2016-01-21 | — | — | US | disclosed |
| US-9220715-B2 | Treatment of addiction and impulse-control disorders using PDE7 inhibitors | OMEROS CORPORATION (US) | 2015-12-29 | — | — | US | disclosed |
| US-9119822-B2 | Use of PDE7 inhibitors for the treatment of movement disorders | OMEROS CORPORATION (US) | 2015-09-01 | — | — | US | disclosed |
| US-20140179717-A1 | Use of PDE7 Inhibitors for the Treatment of Movement Disorders | OMEROS CORPORATION (US) | 2014-06-26 | — | — | US | disclosed |
| US-8637528-B2 | Use of PDE7 inhibitors for the treatment of movement disorders | OMEROS CORPORATION (US) | 2014-01-28 | — | — | US | disclosed |
| US-20130267502-A1 | Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors | OMEROS CORPORATION | 2013-10-10 | — | — | US | disclosed |
| US-20120115849-A1 | Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors | OMEROS CORPORATION | 2012-05-10 | — | — | US | disclosed |
| US-20100227853-A1 | INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES | TRUSTEES OF BOSTON COLLEGE (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100227853-A1 | INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES | TRUSTEES OF BOSTON COLLEGE (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100179158-A1 | INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-07-15 | — | — | US | disclosed |
| US-20100113486-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | OMEROS CORPORATION (US) | 2010-05-06 | — | — | US | disclosed |
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | GILEAD SCIENCES, INC. | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115849-A1 | Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors | PDE7B, PDE4C, PDE4A | TSHR 1528/4885MAPT 3149/4885CASP1 3578/4885 |
| US-20160158247-A1 | Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors | PDE7B, PDE4C, PDE4A | TSHR 1528/4885MAPT 3149/4885CASP1 3578/4885 |
| US-20160015715-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | PARK7, PDE7B, PDE7A | TSHR 2222/4885MAPT 1951/4885CASP1 4458/4885 |
| US-20140179717-A1 | Use of PDE7 Inhibitors for the Treatment of Movement Disorders | PARK7, PDE7B, PDE7A | TSHR 2222/4885MAPT 1951/4885CASP1 4458/4885 |
| US-20100227853-A1 | INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES | PDE7A, PDE4A, PDE4C | TSHR 4049/4885MAPT 3911/4885CASP1 3830/4885 |
| US-20130267502-A1 | Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors | PDE7B, PDE4C, PDE4A | TSHR 1528/4885MAPT 3149/4885CASP1 3578/4885 |
| US-20100113486-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | PARK7, PDE7B, PDE7A | TSHR 2222/4885MAPT 1951/4885CASP1 4458/4885 |
| US-20100179158-A1 | INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES | PDE7A, PDE4A, PDE4C | TSHR 4049/4885MAPT 3911/4885CASP1 3830/4885 |
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | TYMP, PNP, PIKFYVE | TSHR 4778/4885MAPT 2025/4885CASP1 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.