Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55965 | 0.87 | MTNR1A (0.66) | MTNR1AMTNR1BALOX15MEN1CYP1A2 | |
| SCHEMBL9731531 | 0.85 | MTNR1A (0.53) | MTNR1AMTNR1BALOX15MEN1CYP1A2 | |
| SCHEMBL9731445 | 0.80 | MTNR1A (0.53) | MTNR1AMTNR1BALOX15CYP1A2 | |
| SCHEMBL53985 | 0.77 | CYP2C19 (0.74) | MTNR1AMTNR1BALOX15MEN1CYP1A2 | |
| SCHEMBL28453641 | 0.74 | OPRM1 (0.44) | SIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL19879069 | 0.73 | CA1 (0.43) | MTNR1AMTNR1BALOX15MEN1CYP1A2 | |
| SCHEMBL30595323 | 0.73 | MTNR1A (0.77) | MTNR1AMTNR1BGRM7 | |
| SCHEMBL1029693 | 0.73 | MTNR1A (0.77) | MTNR1AMTNR1BGRM7 | |
| SCHEMBL9731433 | 0.73 | MAPT (0.42) | MTNR1AMTNR1BMEN1KMT2ATACR1 | |
| SCHEMBL18650998 | 0.71 | HTR2A (0.57) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071875-A | Nervous system, psychological disorders; sleep cycle, skin dis coloration | NORTHWESTERN UNIVERSITY (US) | 1991-12-10 | — | — | US | claimed |
| EP-0420064-A2 | Substituted 2-amidotetralins as melatonin agonists and antagonists | NORTHWESTERN UNIVERSITY (US) | 1991-04-03 | — | — | EP | claimed |
| EP-2120912-B1 | METHODS OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | CHU SAINTE JUSTINE (CA) | 2013-04-03 | — | — | EP | disclosed |
| US-8222298-B2 | Methods of correcting imbalance between bone resorption and bone formation and kits and compositions therefor | CHU SAINTE-JUSTINE (CA) | 2012-07-17 | — | — | US | disclosed |
| US-20120135930-A1 | METHODS OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | CHU SAINTE-JUSTINE | 2012-05-31 | — | — | US | disclosed |
| US-8129432-B2 | Method of correcting imbalance between bone resorption and bone formation and kits and compositions therefor | CHU SAINTE-JUSTINE (CA) | 2012-03-06 | — | — | US | disclosed |
| US-20100029567-A1 | METHOD OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | CHU SAINTE-JUSTINE (CA) | 2010-02-04 | — | — | US | disclosed |
| EP-2120912-A1 | METHODS OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | Chu Sainte-justine (CA) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008098379-A1 | METHODS OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | CHU SAINTE-JUSTINE (CA) | 2008-08-21 | — | — | WO | disclosed |
| US-5151446-A | Neurological disorders or cardiovascular disorders | NORTHWESTERN UNIVERSITY (US) | 1992-09-29 | — | — | US | disclosed |
| US-5071875-A | Nervous system, psychological disorders; sleep cycle, skin dis coloration | NORTHWESTERN UNIVERSITY (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0420064-A2 | Substituted 2-amidotetralins as melatonin agonists and antagonists | NORTHWESTERN UNIVERSITY (US) | 1991-04-03 | — | — | EP | disclosed |