Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15224202 | 0.83 | MAPK8 (0.45) | MAPK8ALDH1A1KDM4ECXCR5TDP1 | |
| SCHEMBL15224203 | 0.80 | ALDH1A1 (0.44) | MAPK8ALDH1A1KDM4ECXCR5TDP1 | |
| SCHEMBL17685113 | 0.79 | ALDH1A1 (0.46) | MAPK8ALDH1A1KDM4ECXCR5TDP1 | |
| SCHEMBL4638491 | 0.79 | PARP1 (0.65) | MAPK8ALDH1A1KDM4ECXCR5TDP1 | |
| Hydrochloric Acid SCHEMBL2460794 | 0.77 | ALDH1A1 (0.44) | MAPK8ALDH1A1KDM4ECXCR5TDP1 | |
| SCHEMBL4115639 | 0.77 | EPHX2 (0.52) | MAPK8ALDH1A1KDM4ECXCR5 | |
| SCHEMBL10222763 | 0.76 | KDM4E (0.53) | MAPK8ALDH1A1KDM4ECXCR5RAB9A | |
| SCHEMBL31258843 | 0.74 | ALDH1A1 (0.60) | MAPK8ALDH1A1KDM4ECXCR5TDP1 | |
| SCHEMBL1525798 | 0.73 | ALDH1A1 (0.49) | MAPK8ALDH1A1KDM4ECXCR5TDP1 | |
| SCHEMBL15377464 | 0.73 | ALDH1A1 (0.44) | MAPK8ALDH1A1KDM4ECXCR5TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | MAPK8 3085/4885ALDH1A1 2069/4885KDM4E 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.