Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17113647 | 0.86 | MET (0.49) | AXLPRKCIGRM5HTR1AHTR2A | |
| SCHEMBL16493719 | 0.82 | MAPT (0.43) | AXLPRKCIGRM5POLBGAA | |
| SCHEMBL7032135 | 0.81 | GRM5 (0.41) | AXLPRKCIGRM5POLBCOMT | |
| SCHEMBL28111978 | 0.79 | IKBKB (0.48) | AXLPRKCICOMTGAAMEN1 | |
| SCHEMBL1346311 | 0.76 | GRM5 (0.70) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL4307074 | 0.76 | GRM5 (0.35) | AXLPRKCIGRM5POLBCOMT | |
| SCHEMBL15543131 | 0.76 | PRKCI (0.40) | AXLPRKCICOMTGAAMAPT | |
| SCHEMBL27969602 | 0.73 | IKBKB (0.49) | GAAMAPTMEN1KMT2AJAK2 | |
| SCHEMBL28609163 | 0.73 | AXL (0.61) | AXLPRKCIJAK2IKBKBCHUK | |
| SCHEMBL30173316 | 0.73 | AXL (0.61) | AXLPRKCIJAK2IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799691-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006037875-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2006-04-13 | — | — | WO | disclosed |