Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.48 |
| ▸ | CHUK | O15111 | 6/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | COMT | P21964 | 4/20 | 0.46 |
| ▸ | NEK1 | Q96PY6 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17818444 | 0.86 | MET (0.45) | METCOMTGAAMEN1KMT2A | |
| SCHEMBL5137242 | 0.85 | MET (0.64) | IKBKBCHUKMETNEK1PRKCI | |
| SCHEMBL5531006 | 0.79 | AXL (0.54) | IKBKBCHUKCOMTGAAPRKCI | |
| SCHEMBL28094884 | 0.78 | MET (0.76) | METCOMTAXLMEN1KMT2A | |
| SCHEMBL28028675 | 0.78 | IKBKB (0.52) | IKBKBCHUKNEK1PRKCIAXL | |
| SCHEMBL16493719 | 0.77 | MAPT (0.43) | GAAPRKCIAXLMEN1KMT2A | |
| SCHEMBL3616327 | 0.77 | GAA (0.43) | COMTGAAMEN1KMT2A | |
| SCHEMBL27969602 | 0.77 | IKBKB (0.49) | IKBKBCHUKGAAMEN1KMT2A | |
| SCHEMBL7032135 | 0.76 | GRM5 (0.41) | COMTPRKCIAXLMEN1KMT2A | |
| SCHEMBL12605441 | 0.75 | TNNI3K (0.53) | IKBKBCHUKNEK1PRKCIAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106470993-B | The azepine quinazoline inhibitor of Atypical protein kinase C | 癌症研究科技有限公司 | 2019-08-27 | — | — | CN | disclosed |
| CN-106470993-A | The azepine quinazoline inhibitor of Atypical protein kinase C | 癌症研究科技有限公司 | 2017-03-01 | — | — | CN | disclosed |