Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2583226 | 0.87 | ALDH1A1 (0.60) | NPC1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5539191 | 0.85 | SMN1; SMN2 (0.46) | NPC1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL4267589 | 0.76 | KDM4E (0.47) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL15300254 | 0.76 | HTR1A (0.46) | NPC1SMN1; SMN2KMT2AALDH1A1RAB9A | |
| SCHEMBL5532143 | 0.72 | MAPT (0.47) | NPC1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL2585095 | 0.72 | ALDH1A1 (0.55) | NPC1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL2586908 | 0.71 | ALDH1A1 (0.58) | NPC1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL10658160 | 0.70 | HTR2A (0.52) | — | |
| SCHEMBL5533616 | 0.69 | GAA (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1GAA | |
| SCHEMBL5528774 | 0.69 | MAPT (0.47) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869053-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-10-09 | — | — | EP | claimed |
| EP-1869053-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS | Grünenthal GmbH (DE) | 2007-12-26 | — | — | EP | claimed |
| WO-2006105945-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-10-12 | — | — | WO | claimed |
| EP-1869053-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |