Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 11/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 8/20 | 0.42 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5531542 | 0.78 | IMPDH2 (0.44) | PRKCQPRKCDLYNBRD4LRRK2 | |
| SCHEMBL1146649 | 0.77 | BRD4 (0.50) | PRKCQBRD4LRRK2CDK1KDR | |
| SCHEMBL1146651 | 0.73 | LRRK2 (0.49) | PRKCQBRD4LRRK2KDRCYP3A4 | |
| SCHEMBL4951383 | 0.70 | PRKCQ (0.69) | PRKCQPRKCDLYN | |
| SCHEMBL1146652 | 0.69 | IMPDH2 (0.45) | PRKCQBRD4LRRK2CDK1KDR | |
| SCHEMBL5526945 | 0.68 | PRKCQ (0.58) | PRKCQPRKCDLYN | |
| SCHEMBL5531535 | 0.67 | IMPDH2 (0.44) | PRKCQPRKCDLYNLRRK2CYP3A4 | |
| SCHEMBL5518907 | 0.67 | PRKCQ (0.82) | PRKCQPRKCDLYN | |
| SCHEMBL7330846 | 0.66 | NPC1 (0.58) | BRD4 | |
| SCHEMBL5533123 | 0.66 | KDR (0.37) | PRKCQBRD4LRRK2CDK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070082880-A1 | Thieno [2,3-B] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082880-A1 | Thieno [2,3-B] pyridine-5-carbonitriles as protein kinase inhibitors | MAP4K2, CNKSR1, MAP3K1 | PRKCQ 286/4885PRKCD 356/4885LYN 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.