Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.69 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26377827 | 0.92 | GAA (0.83) | GAAL3MBTL1HDAC6HDAC1HDAC3 | |
| SCHEMBL5533585 | 0.89 | L3MBTL1 (0.69) | GAAL3MBTL1HDAC6HDAC1HDAC3 | |
| SCHEMBL6773023 | 0.86 | L3MBTL1 (0.76) | GAAL3MBTL1HDAC6HDAC1HDAC3 | |
| SCHEMBL1930296 | 0.83 | MEN1 (0.70) | GAAL3MBTL1HDAC6HDAC1HDAC3 | |
| SCHEMBL976467 | 0.81 | TSHR (0.68) | GAAL3MBTL1HDAC6HDAC1MEN1 | |
| SCHEMBL352886 | 0.81 | TSHR (0.68) | GAAL3MBTL1MEN1KMT2ATSHR | |
| SCHEMBL12085534 | 0.81 | L3MBTL1 (0.69) | GAAL3MBTL1HDAC6HDAC1HDAC3 | |
| SCHEMBL10927227 | 0.80 | L3MBTL1 (0.58) | GAAL3MBTL1HDAC6HDAC1HDAC3 | |
| SCHEMBL9848204 | 0.79 | KMT2A (0.64) | GAAMEN1KMT2AMAPTTSHR | |
| Hydrochloric Acid SCHEMBL10999011 | 0.79 | L3MBTL1 (0.57) | GAAL3MBTL1HDAC6HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100384418-C | Isoxazolopyridinones and use thereof in the treatment of parkinson's disease | NOVARTIS AG (CH) | 2008-04-30 | — | — | CN | disclosed |
| EP-1418912-B1 | ISOXAZOLOPYRIDINONES | NOVARTIS AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| US-7087756-B2 | Isoxazolopyridinones | NOVARTIS AG (CH) | 2006-08-08 | — | — | US | disclosed |
| CN-1635889-A | Isoxazolopyridinones and their use in the treatment of parkinson's disease | NOVARTIS AG (CH) | 2005-07-06 | — | — | CN | disclosed |
| US-20040248893-A1 | Isoxazolopyridinones | NOVARTIS AG (CH) | 2004-12-09 | — | — | US | disclosed |
| EP-1418912-A2 | ISOXAZOLOPYRIDINONES | Novartis AG (CH) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003015780-A2 | ISOXAZOLOPYRIDINONES AND USE THEREOF IN THE TREATMENT OF PARKINSON'S DISEASE | NOVARTIS AG (CH) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248893-A1 | Isoxazolopyridinones | XDH, NPY1R, TBXA2R | GAA 2766/4885L3MBTL1 4648/4885HDAC6 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.