Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 9/20 | 0.38 |
| ▸ | HRH1 | P35367 | 9/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5533438 | 0.88 | HTR1A (0.38) | KCNH2HRH2HRH1HRH3MEN1 | |
| SCHEMBL4513651 | 0.87 | KCNH2 (0.45) | KCNH2KCNA5HRH2HRH1HRH3 | |
| SCHEMBL4515390 | 0.85 | KCNH2 (0.45) | KCNH2MMP2MMP3HRH2HRH1 | |
| SCHEMBL4518587 | 0.85 | KCNH2 (0.45) | KCNH2MMP2MMP3HRH2HRH1 | |
| SCHEMBL4669159 | 0.85 | KCNH2 (0.49) | KCNH2MMP2KCNA5MMP3HRH2 | |
| SCHEMBL4516621 | 0.84 | KCNH2 (0.50) | KCNH2HRH2HRH1HRH3MEN1 | |
| SCHEMBL4507239 | 0.84 | KCNH2 (0.43) | KCNH2MMP2KCNA5MMP3HRH2 | |
| SCHEMBL4509459 | 0.84 | HRH3 (0.48) | KCNH2MMP2MMP3HRH2HRH1 | |
| SCHEMBL4516179 | 0.83 | KCNH2 (0.47) | KCNH2HRH2HRH1HRH3MEN1 | |
| SCHEMBL4514332 | 0.83 | KCNH2 (0.42) | KCNH2HRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765831-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123747-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |