Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5534239 | 0.88 | KCNH2 (0.43) | HRH1KCNH2HRH2HRH3MEN1 | |
| SCHEMBL4505273 | 0.83 | HRH1 (0.37) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL5116804 | 0.83 | KCNH2 (0.42) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL4516179 | 0.83 | KCNH2 (0.47) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL4513667 | 0.83 | OPRM1 (0.40) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL4508018 | 0.82 | GPR119 (0.40) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| Hydrochloric Acid SCHEMBL4521680 | 0.82 | KCNH2 (0.36) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL4512005 | 0.82 | KCNH2 (0.36) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL4669141 | 0.82 | OPRM1 (0.44) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL4523088 | 0.81 | KCNH2 (0.37) | HTR1ADRD4HTR2AHRH1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765831-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | claimed |
| WO-2005123747-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | claimed |