Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 2/20 | 0.59 |
| ▸ | GRK3 | P35626 | 2/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | NAMPT | P43490 | 3/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | GRK5 | P34947 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000282 | 0.80 | ROCK2 (0.60) | GRK2ROCK2MEN1KMT2AGAA | |
| SCHEMBL28901871 | 0.80 | MEN1 (0.54) | GRK2GRK3ROCK2MEN1KMT2A | |
| SCHEMBL11617698 | 0.75 | NAMPT (0.82) | MEN1KMT2ANAMPTMTORNPC1 | |
| SCHEMBL14496332 | 0.74 | GRK2 (1.00) | GRK2GRK3ROCK2MEN1KMT2A | |
| SCHEMBL5289108 | 0.73 | MEN1 (0.54) | GRK2GRK3ROCK2MEN1KMT2A | |
| SCHEMBL3905327 | 0.72 | KDR (0.53) | GRK2GRK3ROCK2MEN1KMT2A | |
| SCHEMBL157003 | 0.71 | MEN1 (0.56) | GRK2GRK3ROCK2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30605752 | 0.71 | MEN1 (0.56) | GRK2GRK3ROCK2MEN1KMT2A | |
| SCHEMBL30421886 | 0.71 | MEN1 (0.56) | GRK2GRK3ROCK2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28590040 | 0.71 | MEN1 (0.56) | GRK2GRK3ROCK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135499-A1 | Hydrazide compounds | AERIE PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070135499-A1 | Hydrazide compounds | AERIE PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070135499-A1 | Hydrazide compounds | AERIE PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | US | disclosed |
| WO-2007008942-A2 | PHENYLAMINO-ACETIC ACID [1-(PYRIDIN-4-YL)-METHYLIDENE]-HYDRAZIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF G PROTEIN-COUPLED RECEPTOR KINASES FOR THE TREATMENT OF EYE DISEASES | AERIE PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135499-A1 | Hydrazide compounds | GRK4, GRK2, GRK1 | GRK2 2/4885GRK3 4/4885ROCK2 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.