Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | GRK2 | P25098 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | FLT1 | P17948 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL631634 | 0.84 | LMNA (0.59) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL632349 | 0.84 | EGFR (0.59) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL6000398 | 0.84 | ALDH1A1 (0.49) | ROCK2GRK2KDRFLT1ALDH1A1 | |
| SCHEMBL3905327 | 0.83 | KDR (0.53) | ROCK2GRK2KDRALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7102271 | 0.82 | LMNA (0.58) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL2908532 | 0.82 | LTA4H (0.66) | ALDH1A1MAPTNAMPTMEN1KMT2A | |
| SCHEMBL632217 | 0.82 | CHRM2 (0.55) | ROCK2GRK2ALDH1A1MAPTMEN1 | |
| SCHEMBL5534294 | 0.80 | GRK2 (0.59) | ROCK2GRK2KDRFLT1ALDH1A1 | |
| SCHEMBL11510373 | 0.80 | GAA (0.51) | ROCK2GRK2ALDH1A1MAPTMEN1 | |
| SCHEMBL5998792 | 0.79 | FLT1 (0.55) | GRK2KDRFLT1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058357-A1 | Delta2-1,2,3-triazoline anticonvulsants and their active metabolite analogues, the aminoalkylpyridines, are excitatory amino acid antagonists and antiischemic agents, useful in the treatment of cerebral ischemia resulting from stroke | K AND K BIOSCIENCE, INC. (US) | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058357-A1 | Delta2-1,2,3-triazoline anticonvulsants and their active metabolite analogues, the aminoalkylpyridines, are excitatory amino acid antagonists and antiischemic agents, useful in the treatment of cerebral ischemia resulting from stroke | SIGMAR1, GRM1, GRIN2C | ROCK2 3288/4885GRK2 121/4885KDR 651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.