Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | UBE2M | P61081 | 2/20 | 0.48 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28741984 | 0.82 | OPRM1 (0.53) | OPRM1KCNH2SIGMAR1ACHEPKM | |
| SCHEMBL20762328 | 0.81 | MEN1 (0.51) | OPRM1SIGMAR1 | |
| SCHEMBL9884888 | 0.81 | OPRM1 (0.52) | OPRM1KCNH2SIGMAR1ACHECHRM2 | |
| SCHEMBL5535246 | 0.80 | TACR1 (0.45) | DCUN1D1 | |
| SCHEMBL20762351 | 0.80 | OPRM1 (0.50) | OPRM1SIGMAR1BCHEACHE | |
| SCHEMBL20762603 | 0.80 | MEN1 (0.51) | OPRM1SIGMAR1 | |
| SCHEMBL12355143 | 0.80 | HSD11B1 (0.47) | OPRM1KCNH2SIGMAR1BCHEACHE | |
| SCHEMBL4178459 | 0.80 | CHRM2 (0.51) | OPRM1SIGMAR1ACHECHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL8479224 | 0.80 | OPRM1 (0.51) | OPRM1SIGMAR1UBE2MDCUN1D1BCHE | |
| SCHEMBL8578092 | 0.80 | HSD11B1 (0.48) | OPRM1KCNH2SIGMAR1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | OPRM1 518/4885KCNH2 3503/4885SIGMAR1 234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.