Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.68 |
| ▸ | MGLL | Q99685 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.59 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.56 |
| ▸ | LSS | P48449 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | MAPK7 | Q13164 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27629727 | 0.83 | HPGD (0.65) | HSD11B1MGLLHRH3EPHX2LSS | |
| SCHEMBL25988870 | 0.81 | HSD11B1 (0.57) | HSD11B1MGLLHRH3EPHX2LSS | |
| SCHEMBL5546406 | 0.81 | HSD11B1 (0.60) | HSD11B1MGLLHRH3EPHX2HTR2B | |
| SCHEMBL12576441 | 0.81 | HSD11B1 (1.00) | HSD11B1MGLL | |
| SCHEMBL13841325 | 0.81 | EPHX2 (0.81) | HSD11B1MGLLHRH3EPHX2LSS | |
| SCHEMBL27492566 | 0.81 | HRH3 (0.60) | HSD11B1MGLLHRH3EPHX2LSS | |
| SCHEMBL5450590 | 0.81 | HRH3 (0.60) | HSD11B1MGLLHRH3EPHX2LSS | |
| SCHEMBL1812101 | 0.80 | MGLL (0.74) | HSD11B1MGLLHRH3EPHX2LSS | |
| SCHEMBL17014217 | 0.80 | HSD11B1 (0.59) | HSD11B1MGLLHRH3EPHX2LSS | |
| SCHEMBL5536446 | 0.80 | GAA (0.71) | HSD11B1MGLLGRM3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102532162-B | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| CN-101255170-A | 2,3-dihydroimidazo[2,1-b]oxazole compound | OTSUKA PHARMA CO LTD (JP) | 2008-09-03 | — | — | CN | disclosed |
| CN-101172981-A | 2,3-dihydroimidazo[2,1-b]oxazole compound | OTSUKA PHARMA CO LTD (JP) | 2008-05-07 | — | — | CN | disclosed |
| CN-100366624-C | 2, 3-dihydro-6-nitroimidazo [2,1-b ] * azole compounds | OTSUKA PHARMA CO LTD (JP) | 2008-02-06 | — | — | CN | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| CN-1705670-A | 2, 3-dihydro-6-nitroimidazo [2, 1-b ] oxazole compounds | OTSUKA PHARMA CO LTD (JP) | 2005-12-07 | — | — | CN | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | HSD11B1 256/4885MGLL 4717/4885HRH3 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.