Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.51 |
| ▸ | WNT1 | P04628 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22043996 | 0.82 | RIPK1 (0.51) | PARP1APPBCHEACHE | |
| SCHEMBL14570476 | 0.80 | NEK1 (0.50) | APPBCHEACHEHPGD | |
| SCHEMBL5541202 | 0.79 | CAMKK2 (0.39) | HPGDS | |
| SCHEMBL5534980 | 0.79 | MAPK3 (0.52) | SMN1; SMN2 | |
| SCHEMBL5537482 | 0.78 | ADORA2A (0.52) | HPGDSDYRK1ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL5538004 | 0.77 | KMT2A (0.43) | DYRK1ASMN1; SMN2HPGD | |
| SCHEMBL22044070 | 0.77 | MAPT (0.52) | DYRK1ASMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL22044137 | 0.77 | NPC1 (0.48) | PARP1SMN1; SMN2 | |
| SCHEMBL22044004 | 0.76 | ADORA2A (0.43) | CYP1A2CYP2D6CYP2C19HPGD | |
| SCHEMBL22044077 | 0.76 | KDM4E (0.51) | SMN1; SMN2CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186716-B2 | 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors | SUGEN, INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186716-B2 | 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors | SUGEN, INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186716-B2 | 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors | SUGEN, INC. (US) | 2007-03-06 | — | — | US | disclosed |