Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.61 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2255423 | 0.92 | DGAT1 (0.56) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL2255419 | 0.92 | DGAT1 (0.56) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL2258532 | 0.85 | DGAT1 (0.78) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL2258528 | 0.85 | DGAT1 (0.78) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| Hydrochloric Acid SCHEMBL2255386 | 0.84 | DGAT1 (0.77) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| Hydrochloric Acid SCHEMBL2255383 | 0.84 | DGAT1 (0.77) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL5537381 | 0.82 | DGAT1 (0.74) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL2255755 | 0.79 | DGAT1 (0.79) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL2255759 | 0.79 | DGAT1 (0.79) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL5534475 | 0.78 | DGAT1 (0.76) | DGAT1SOAT1FAAHCHRM2DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108602-A1 | Carbamoyl Compounds as DGAT1 Inhibitors 190 | ASTRAZENECA AB (SE) | 2012-05-03 | — | — | US | disclosed |
| US-20120108602-A1 | Carbamoyl Compounds as DGAT1 Inhibitors 190 | ASTRAZENECA AB (SE) | 2012-05-03 | — | — | US | disclosed |
| US-7994179-B2 | Carbamoyl compounds as DGAT1 inhibitors 190 | ASTRAZENECA AB (SE) | 2011-08-09 | — | — | US | disclosed |
| US-20090298853-A1 | Carbamoyl Compounds as DGAT1 Inhibitors 190 | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
| WO-2009081195-A1 | CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190 | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108602-A1 | Carbamoyl Compounds as DGAT1 Inhibitors 190 | DGAT1, DGAT2, SOAT1 | DGAT1 1/4885SOAT1 3/4885FAAH 979/4885 |
| US-20090298853-A1 | Carbamoyl Compounds as DGAT1 Inhibitors 190 | DGAT1, DGAT2, SOAT1 | DGAT1 1/4885SOAT1 3/4885FAAH 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.