SCHEMBL553792

SCHEMBL553792

ON1C=CCc2ccccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.35
MITF O75030 1/20 0.35
RAB9A P51151 1/20 0.35
SIGMAR1 Q99720 2/20 0.34
AADAT Q8N5Z0 2/20 0.34
GOT1 P17174 1/20 0.34
KYAT1 Q16773 1/20 0.34
KYAT3 Q6YP21 1/20 0.34
POLB P06746 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
ALDH1A1 P00352 2/20 0.32
NOTUM Q6P988 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
HTR2A P28223 1/20 0.32
HPGD P15428 1/20 0.32
USP2 O75604 1/20 0.32
CDK4 P11802 1/20 0.32
ALOX15 P16050 1/20 0.32
CCND1 P24385 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL374979 0.76 ALDH1A1 (0.33) NPC1MITFRAB9ASIGMAR1POLB
SCHEMBL4838387 0.74 HTR2A (0.36) NPC1MITFRAB9ASIGMAR1AADAT
SCHEMBL15010759 0.74 POLB (0.33) NPC1MITFRAB9ASIGMAR1POLB
SCHEMBL2073990 0.74 HTR2A (0.36) NPC1MITFRAB9ASIGMAR1AADAT
SCHEMBL1198917 0.74 ALDH1A1 (0.36) RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL1375450 0.74 NPC1 (0.35) NPC1MITFRAB9APOLBSMN1; SMN2
SCHEMBL10760096 0.74 NPC1 (0.36) NPC1MITFRAB9ASIGMAR1POLB
SCHEMBL10342888 0.74 SRD5A1 (0.45) NOTUMHTR2ATSHR
SCHEMBL5894079 0.72 TLR9 (0.35) NPC1RAB9AAADATGOT1KYAT1
SCHEMBL10785337 0.72 POLB (0.33) NPC1MITFRAB9APOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117509577-A Method for extracting phosphorus and reducing aluminum in wet phosphoric acid process by semi-water-dihydrate method 宜都兴发化工有限公司 2024-02-06 CN claimed
WO-2004026896-A2 HCV NS-3 SERINE PROTEASE INHIBITORS MEDIVIR AB (SE) 2004-04-01 WO claimed
US-5624933-A Process for the preparation of a 6-fluoro-2-halo-quinoline RHONE-POULENC RORER S.A. (FR) 1997-04-29 US claimed
US-5182213-A Coupling a Phenylenediamine and a Naphthol MILES INC. (US) 1993-01-26 US claimed
EP-0504663-A1 Peroxidase indicator system for basic media Bayer Corporation (US) 1992-09-23 EP claimed
JP-54112876-A None JP disclosed
CN-112753095-B Polishing composition for silicon oxide film 花王株式会社 2025-01-10 CN disclosed
CN-115504933-B Preparation method and application of polysubstituted quinolinone compound 深圳万知达企业管理有限公司 2024-12-13 CN disclosed
CN-114616234-B Phosphorus imidazoquinoline amine derivative, pharmaceutical composition and application thereof 康威(广州)生物科技有限公司 2024-04-12 CN disclosed
CN-117509577-A Method for extracting phosphorus and reducing aluminum in wet phosphoric acid process by semi-water-dihydrate method 宜都兴发化工有限公司 2024-02-06 CN disclosed
US-11814547-B2 Polishing liquid composition for silicon oxide film KAO CORPORATION (JP) 2023-11-14 US disclosed
CN-115304499-A Condensed cyclic compound and organic light-emitting device including the same 三星显示有限公司 2022-11-08 CN disclosed
CN-1835944-A Quinolyl amide derivatives as CCR-5 antagonists SCHERING AG (DE) 2006-09-20 CN disclosed
WO-2006028962-A2 1-ALKOXY 1H-IMIDAZO RING SYSTEMS AND METHODS 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-03-16 WO disclosed
US-20050131019-A1 Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) ABBVIE INC. 2005-06-16 US disclosed
WO-2005023762-A1 PYRROLIDINE-2-CARBONITRILE DERIVATIVES AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) ABBOTT LABORATORIES (US) 2005-03-17 WO disclosed
JP-2001226355-A NEW 1-HYDROXYQUINOLINE DERIVATIVE YAMANOUCHI PHARMACEUT CO LTD 2001-08-21 JP disclosed
US-5182213-A Coupling a Phenylenediamine and a Naphthol MILES INC. (US) 1993-01-26 US disclosed
EP-0504663-A1 Peroxidase indicator system for basic media Bayer Corporation (US) 1992-09-23 EP disclosed
JP-S54112876-A PREPARATION OF 1-SUBSTITUTED-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID DERIVATIVES SUMITOMO CHEM CO LTD 1979-09-04 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050131019-A1 Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) DPP4, DPP3, DPP7 NPC1 363/4885MITF 3204/4885RAB9A 3842/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.