SCHEMBL5539892

SCHEMBL5539892

CCCCCC(=O)Nc1ccc([O])cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.65
CA2 P00918 2/20 0.65
PSMB11 A5LHX3 2/20 0.61
PSMA7 O14818 2/20 0.61
PSMB1 P20618 2/20 0.61
PSMA1 P25786 2/20 0.61
PSMA2 P25787 2/20 0.61
PSMA3 P25788 2/20 0.61
PSMA4 P25789 2/20 0.61
PSMB8 P28062 2/20 0.61
PSMB9 P28065 2/20 0.61
PSMA5 P28066 2/20 0.61
PSMB4 P28070 2/20 0.61
PSMB6 P28072 2/20 0.61
PSMB5 P28074 2/20 0.61
PSMB10 P40306 2/20 0.61
PSMB3 P49720 2/20 0.61
PSMB2 P49721 2/20 0.61
PSMA6 P60900 2/20 0.61
PSMA8 Q8TAA3 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11335630 0.98 ENPP2 (0.64) CA1CA2PSMB11PSMA7PSMB1
SCHEMBL5537059 0.95 ALDH1A1 (0.64) CA1CA2PSMB11PSMA7PSMB1
SCHEMBL9858666 0.91 ENPP2 (0.71) CA1CA2PSMB11PSMA7PSMB1
SCHEMBL9510547 0.91 ENPP2 (0.71) CA1CA2PSMB11PSMA7PSMB1
SCHEMBL675018 0.91 ENPP2 (0.71) CA1CA2PSMB11PSMA7PSMB1
SCHEMBL5542468 0.87 TP53 (0.75) CA1CA2HPGDNPC1RAB9A
SCHEMBL10782872 0.86 PSMB11 (0.80) CA1CA2PSMB11PSMA7PSMB1
SCHEMBL26420478 0.86 HDAC3 (0.75) CA1CA2PSMB11PSMA7PSMB1
SCHEMBL7264242 0.84 PSMB11 (0.83) CA1CA2PSMB11PSMA7PSMB1
SCHEMBL13510734 0.84 PSMB11 (0.83) CA1CA2PSMB11PSMA7PSMB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4113495-A 2,4,4-TRIMETHYL-2-(2,5-DIHYDROXYPHENYL)-6-HYDROXY-CHROMANS FUJI PHOTO FILM CO., LTD. (JP) 1978-09-12 US claimed
EP-2570418-A2 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2013-03-20 EP disclosed
EP-1555267-B1 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES OTSUKA PHARMA CO LTD (JP) 2013-01-16 EP disclosed
US-7262212-B2 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-08-28 US disclosed
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-05-04 US disclosed
EP-1555267-A1 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-07-20 EP disclosed
EP-0778267-A1 SULFONAMIDE DERIVATIVES AND INSECTICIDE, MITICIDE AND NEMATICIDE CONTAINING THE SAME OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1997-06-11 EP disclosed
US-5043460-A Discoloration inhibition; color photography FUJI PHOTO FILM CO., LTD. (JP) 1991-08-27 US disclosed
US-4745050-A Silver halide color photographic material and discoloration inhibitor therefor FUJI PHOTO FILM CO., LTD. (JP) 1988-05-17 US disclosed
US-4367272-A MORDANTS, REFLECTION FUJI PHOTO FILM CO., LTD (JP) 1983-01-04 US disclosed
US-4264720-A CHROMENE COMPOUND COLOR STABILIZING AGENT FUJI PHOTO FILM CO., LTD. (JP) 1981-04-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles NR2C2, NR4A3, NR4A2 CA1 3493/4885CA2 1853/4885PSMB11 2367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.