Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL259712 | 0.99 | LMNA (0.39) | LMNAALDH1A1KDM4ENPC1GAA | |
| SCHEMBL5540182 | 0.97 | LMNA (0.38) | LMNAALDH1A1KDM4ENPC1GAA | |
| SCHEMBL2054568 | 0.91 | KDM4E (0.43) | LMNAALDH1A1KDM4ENPC1GAA | |
| SCHEMBL261021 | 0.84 | ALDH1A1 (0.43) | LMNAALDH1A1KDM4ENPC1GAA | |
| SCHEMBL260808 | 0.84 | KDM4E (0.50) | LMNAALDH1A1KDM4ENPC1GAA | |
| SCHEMBL261770 | 0.83 | KDM4E (0.41) | ALDH1A1KDM4ENPC1GAASMN1; SMN2 | |
| SCHEMBL14538682 | 0.74 | KDM4E (0.47) | LMNAALDH1A1KDM4ENPC1GAA | |
| SCHEMBL260929 | 0.72 | APEX1 (0.57) | KDM4ENPC1GAAMEN1KMT2A | |
| SCHEMBL260928 | 0.72 | APEX1 (0.57) | KDM4ENPC1GAAMEN1KMT2A | |
| SCHEMBL18171837 | 0.71 | ALDH1A1 (0.49) | ALDH1A1KDM4ENPC1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794146-A2 | TRICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006031676-A2 | TRICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-03-23 | — | — | WO | disclosed |