Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.70 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.70 |
| ▸ | DRD2 | P14416 | 3/20 | 0.70 |
| ▸ | HTR2B | P41595 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.65 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 9/20 | 0.61 |
| ▸ | HTR2A | P28223 | 8/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | HTR1D | P28221 | 2/20 | 0.55 |
| ▸ | HTR1B | P28222 | 2/20 | 0.55 |
| ▸ | HTR1E | P28566 | 2/20 | 0.55 |
| ▸ | HTR5A | P47898 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31639048 | 0.90 | HTR7 (0.67) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL14043228 | 0.89 | HTR7 (0.71) | HTR7CHRM4DRD2HTR2BMAPT | |
| Bromide SCHEMBL6569631 | 0.88 | HTR7 (0.70) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL6240399 | 0.88 | HTR7 (0.70) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL8035748 | 0.86 | KMT2A (0.76) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL6237686 | 0.86 | KMT2A (0.76) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL23116691 | 0.85 | HTR7 (0.67) | HTR7CHRM4DRD2HTR2BMAPT | |
| Hydrochloric Acid SCHEMBL6350788 | 0.85 | KMT2A (0.77) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL6237647 | 0.84 | HTR7 (0.66) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL5538606 | 0.83 | HTR2A (0.62) | HTR2BHTR2CHTR2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007147819-A1 | 3H,11H-OXAZOLO[3',4':1,2]PYRIDO[3,4-B]INDOLE DERIVATIVES AND THERAPEUTIC USE THEREOF | FOURTILLAN (FR) | 2007-12-27 | — | — | WO | disclosed |
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-23 | — | — | US | disclosed |
| WO-2005009370-A2 | BETA-CARBOLINE COMPOUNDS AND ANALOGUES THEREOF AND THEIR USE AS MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS | PHARMACIA CORPORATION (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | MAPKAPK2, MAP4K2, MAP3K2 | HTR7 1500/4885CHRM4 2199/4885DRD2 1255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.