Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.53 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.53 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.53 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 4/20 | 0.70 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.70 |
| ▸ | DRD2 | P14416 | 3/20 | 0.70 |
| ▸ | HTR2A | P28223 | 9/20 | 0.69 |
| ▸ | HTR2C | P28335 | 9/20 | 0.69 |
| ▸ | HTR2B | P41595 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.62 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14043228 | 0.99 | HTR7 (0.71) | HTR7CHRM4DRD2HTR2AHTR2C | |
| SCHEMBL5541281 | 0.88 | HTR7 (0.70) | HTR7CHRM4DRD2HTR2AHTR2C | |
| SCHEMBL6240399 | 0.88 | HTR7 (0.70) | HTR7CHRM4DRD2HTR2AHTR2C | |
| SCHEMBL23116691 | 0.85 | HTR7 (0.67) | HTR7CHRM4DRD2HTR2AHTR2C | |
| SCHEMBL31639048 | 0.85 | HTR7 (0.67) | HTR7CHRM4DRD2HTR2AHTR2C | |
| SCHEMBL20186486 | 0.85 | HTR7 (0.64) | HTR7CHRM4DRD2HTR2AHTR2C | |
| SCHEMBL6237647 | 0.84 | HTR7 (0.66) | HTR7CHRM4DRD2HTR2AHTR2C | |
| SCHEMBL8035748 | 0.83 | KMT2A (0.76) | HTR7CHRM4DRD2HTR2AHTR2C | |
| SCHEMBL6237686 | 0.83 | KMT2A (0.76) | HTR7CHRM4DRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL6350788 | 0.82 | KMT2A (0.77) | HTR7CHRM4DRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1433801-A1 | Composition for a resin | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2004-06-30 | — | — | EP | disclosed |
| EP-0936233-B1 | Composition for a resin | MITSUBISHI GAS CHEMICAL CO (JP) | 2004-04-21 | — | — | EP | disclosed |
| US-6201061-B1 | CURING A RESIN FOR OPTICAL USE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2001-03-13 | — | — | US | disclosed |
| EP-0950905-A2 | Process for producing a novel resin for optical materials having excellent color tone and transparency | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1999-10-20 | — | — | EP | disclosed |
| EP-0936233-A2 | Composition for a resin | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1999-08-18 | — | — | EP | disclosed |