Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5265951 | 0.90 | POLB (0.44) | POLBMEN1KMT2A | |
| SCHEMBL6961333 | 0.86 | POLB (0.39) | POLBMEN1KMT2A | |
| SCHEMBL7444323 | 0.86 | POLB (0.41) | POLBMEN1KMT2A | |
| SCHEMBL7561336 | 0.82 | MEN1 (0.41) | MEN1KMT2A | |
| SCHEMBL6504166 | 0.79 | POLB (0.34) | POLBTDP1MEN1KMT2ANOS1 | |
| SCHEMBL6506502 | 0.79 | POLB (0.35) | POLBMEN1KMT2ANOS1NOS2 | |
| SCHEMBL6683579 | 0.78 | POLB (0.37) | POLBMEN1KMT2A | |
| SCHEMBL7562738 | 0.77 | POLB (0.36) | POLBMAOBMEN1KMT2A | |
| SCHEMBL8370371 | 0.77 | ESR2 (0.43) | CYP3A4 | |
| SCHEMBL8371294 | 0.77 | CYP2A6 (0.35) | POLBMAOBTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751131-A1 | MTP INHIBITING ARYL PIPERIDINES OR PIPERAZINES SUBSTITUTED WITH 5-MEMBERED HETEROCYCLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005085226-A1 | MTP INHIBITING ARYL PIPERIDINES OR PIPERAZINES SUBSTITUTED WITH 5-MEMBERED HETEROCYCLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-09-15 | — | — | WO | disclosed |