Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | USP7 | Q93009 | 5/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13674535 | 1.00 | HSD11B1 (0.37) | HSD11B1ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL13674534 | 0.92 | HSD11B1 (0.40) | HSD11B1ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL4517259 | 0.92 | HSD11B1 (0.40) | HSD11B1ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL4528144 | 0.91 | ACVRL1 (0.38) | HSD11B1ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL13674541 | 0.91 | ACVRL1 (0.38) | HSD11B1ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL13675550 | 0.91 | HSD11B1 (0.36) | HSD11B1USP7ROCK2CHKAP2RX7 | |
| SCHEMBL13674533 | 0.88 | ACVRL1 (0.36) | HSD11B1ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL4518204 | 0.88 | ACVRL1 (0.38) | HSD11B1ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL4516016 | 0.88 | ACVRL1 (0.36) | HSD11B1ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL13674537 | 0.88 | ACVRL1 (0.38) | HSD11B1ACVRL1ACVR1BMPR1ABMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1864971-A1 | PROPHYLACTIC/THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2007-12-12 | — | — | EP | disclosed |