Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20707157 | 1.00 | NAMPT (0.67) | NAMPTHDAC3HDAC1SIGMAR1MAPK1 | |
| SCHEMBL5546309 | 1.00 | NAMPT (0.67) | NAMPTHDAC3HDAC1SIGMAR1MAPK1 | |
| SCHEMBL5515823 | 1.00 | NAMPT (0.67) | NAMPTHDAC3HDAC1SIGMAR1MAPK1 | |
| SCHEMBL5536198 | 0.98 | NAMPT (0.64) | NAMPTHDAC3HDAC1SIGMAR1MAPK1 | |
| SCHEMBL19133513 | 0.94 | NAMPT (0.61) | NAMPTHDAC3HDAC1SIGMAR1MAPK1 | |
| SCHEMBL28929238 | 0.92 | L3MBTL1 (0.68) | NAMPTHDAC3HDAC1SIGMAR1MAPK1 | |
| SCHEMBL22265515 | 0.92 | L3MBTL1 (0.68) | NAMPTHDAC3HDAC1SIGMAR1MAPK1 | |
| SCHEMBL19133485 | 0.92 | HDAC3 (0.62) | NAMPTHDAC3HDAC1SIGMAR1MAPK1 | |
| SCHEMBL7391759 | 0.92 | POLB (0.60) | NAMPTHDAC3HDAC1SIGMAR1MAPK1 | |
| SCHEMBL17623676 | 0.90 | SIGMAR1 (0.60) | NAMPTHDAC3HDAC1SIGMAR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262223-B2 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-08-28 | — | — | US | disclosed |
| US-7262223-B2 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-08-28 | — | — | US | disclosed |
| EP-1715857-A1 | AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS | Neurochem (International) Limited (CH) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005079780-A1 | AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-09-01 | — | — | WO | disclosed |
| US-20050182118-A1 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182118-A1 | Amidine derivatives for treating amyloidosis | APP, IAPP, GRN | NAMPT 131/4885HDAC3 3707/4885HDAC1 3555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.