Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 3/20 | 0.53 |
| ▸ | F2 | P00734 | 2/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.53 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.53 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | S100B | P04271 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | AOC1 | P19801 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentamidine Dao SCHEMBL548448 | 0.92 | PRMT1 (0.61) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL548439 | 0.90 | PRSS1 (0.60) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL549185 | 0.86 | TMPRSS2 (0.60) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL7341007 | 0.84 | TP53 (0.59) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL6510086 | 0.84 | TP53 (0.59) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL15020066 | 0.84 | TP53 (0.59) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL8718224 | 0.82 | TP53 (0.57) | PRSS1GAALMNARAB9ANPC1 | |
| SCHEMBL6407420 | 0.81 | MMP1 (0.56) | TMPRSS2CYP2D6PRSS1GAARAB9A | |
| SCHEMBL20332718 | 0.81 | TMPRSS2 (0.55) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL409427 | 0.80 | NR1I2 (0.53) | PRMT1F2ST14TMPRSS2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262223-B2 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-08-28 | — | — | US | claimed |
| EP-1715857-A1 | AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS | Neurochem (International) Limited (CH) | 2006-11-02 | — | — | EP | claimed |
| WO-2005079780-A1 | AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-09-01 | — | — | WO | claimed |
| US-20050182118-A1 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-08-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182118-A1 | Amidine derivatives for treating amyloidosis | APP, IAPP, GRN | PRMT1 194/4885F2 3712/4885ST14 3028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.