Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.50 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8718224 | 0.97 | TP53 (0.57) | MMP1GAARAB9ATP53TSHR | |
| SCHEMBL15020066 | 0.95 | TP53 (0.59) | CYP2D6GAARAB9ATP53TSHR | |
| SCHEMBL7341007 | 0.95 | TP53 (0.59) | CYP2D6GAARAB9ATP53TSHR | |
| SCHEMBL6510086 | 0.95 | TP53 (0.59) | CYP2D6GAARAB9ATP53TSHR | |
| SCHEMBL3275310 | 0.93 | PLK1 (0.56) | MMP1CYP1A2KDM4ECYP2D6PDE4A | |
| SCHEMBL548439 | 0.91 | PRSS1 (0.60) | CYP2D6GAAPRSS1TMPRSS2 | |
| SCHEMBL549185 | 0.91 | TMPRSS2 (0.60) | MMP1CYP2D6PRSS1TMPRSS2 | |
| Pentamidine Dao SCHEMBL548448 | 0.89 | PRMT1 (0.61) | CYP2D6GAAPRSS1TMPRSS2 | |
| Maleic Acid SCHEMBL6407424 | 0.88 | MMP1 (0.53) | MMP1CYP1A2KDM4ECYP2D6PDE4A | |
| SCHEMBL23588050 | 0.86 | TMPRSS2 (0.51) | MMP1CYP2D6PRSS1TMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861071-B1 | BENZAMIDOXIME PRODRUGS AND USE THEREOF FOR TREATING PNEUMONIA | UNIV NORTH CAROLINA (US) | 2005-05-11 | — | — | EP | claimed |
| WO-2024089421-A1 | TETRAZOLE DERIVATIVES | SITRYX THERAPEUTICS LIMITED (GB) | 2024-05-02 | — | — | WO | disclosed |
| US-20230219907-A1 | CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES | SITRYX THERAPEUTICS LIMITED (GB) | 2023-07-13 | — | — | US | disclosed |
| US-20230219907-A1 | CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES | SITRYX THERAPEUTICS LIMITED (GB) | 2023-07-13 | — | — | US | disclosed |
| CN-115066418-A | Carboxy derivatives with anti-inflammatory properties | 西特瑞治疗有限公司 | 2022-09-16 | — | — | CN | disclosed |
| WO-2021130492-A1 | CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES | SITRYX THERAPEUTICS LIMITED (GB) | 2021-07-01 | — | — | WO | disclosed |
| EP-1561463-A2 | Benzamidoxime prodrugs as antipneumocystic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-0861071-B1 | BENZAMIDOXIME PRODRUGS AND USE THEREOF FOR TREATING PNEUMONIA | UNIV NORTH CAROLINA (US) | 2005-05-11 | — | — | EP | disclosed |
| US-6423737-B2 | Benzamidoxime prodrugs as antipneumocystic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2002-07-23 | — | — | US | disclosed |
| US-20010044468-A1 | Benzamidoxime prodrugs as antipneumocystic agents | HALL JAMES E (US) | 2001-11-22 | — | — | US | disclosed |
| US-6214883-B1 | BIS//N-HYDROXYAMIDINO/PHENOXY OR -THIO/ALKANES REDUCED AFTER ORAL ADMINISTRATION TO THE CORRESPONDING MONO- OR BISAMIDINES | THE GEORGIA STATE UNIVERSITY | 2001-04-10 | — | — | US | disclosed |
| US-6025398-A | Benzamidoxime prodrugs as antipneumocystic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-02-15 | — | — | US | disclosed |
| US-5843980-A | Benzamidoxime prodrugs as antipneumocystic agents | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0861071-A1 | BENZAMIDOXIME PRODRUGS AS ANTIPNEUMOCYSTIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5723495-A | TREATMENT OF PNEUMONIA | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-03-03 | — | — | US | disclosed |
| WO-1997017949-A1 | BENZAMIDOXIME PRODRUGS AS ANTIPNEUMOCYSTIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044468-A1 | Benzamidoxime prodrugs as antipneumocystic agents | BHMT, BBOX1, BCHE | MMP1 225/4885CYP1A2 597/4885KDM4E 2197/4885 |
| US-20230219907-A1 | CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES | CPA2, RO60, C5AR1 | MMP1 281/4885CYP1A2 820/4885KDM4E 1568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.