Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5544896 | 0.72 | MEN1 (0.46) | ALDH1A1SMN1; SMN2KMT2AMEN1PABPC1 | |
| SCHEMBL11806 | 0.60 | NPC1 (0.85) | ALDH1A1KMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL13959947 | 0.59 | NPC1 (0.72) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2683082 | 0.58 | LMNA (0.60) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14460307 | 0.58 | RAB9A (0.97) | ALDH1A1SMN1; SMN2KMT2AMEN1L3MBTL1 | |
| SCHEMBL279859 | 0.58 | HTT (0.63) | SMN1; SMN2KMT2AMEN1NPC1RAB9A | |
| SCHEMBL23573447 | 0.57 | NPC1 (0.78) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL30804727 | 0.57 | NPC1 (0.68) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9179058 | 0.57 | KAT6A (0.74) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23573449 | 0.57 | NPC1 (0.78) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |