Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 10/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16456577 | 0.89 | TLR8 (0.52) | TLR8TLR7 | |
| SCHEMBL5090696 | 0.89 | TLR8 (0.46) | TLR8TLR7GPR119 | |
| SCHEMBL5090688 | 0.80 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL2401186 | 0.75 | TLR8 (0.59) | TLR8TLR7 | |
| SCHEMBL5087214 | 0.74 | TLR8 (0.58) | TLR8TLR7 | |
| SCHEMBL5087087 | 0.74 | GPR119 (0.43) | GPR119 | |
| SCHEMBL1528031 | 0.73 | TLR8 (0.65) | TLR8TLR7 | |
| SCHEMBL5087268 | 0.73 | TLR8 (0.48) | TLR8TLR7 | |
| SCHEMBL15379831 | 0.73 | LMNA (0.49) | P2RY12GPR119 | |
| SCHEMBL5095707 | 0.73 | TLR8 (0.59) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846419-A2 | ALKYLOXY SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006086449-A2 | ALKYLOXY SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-08-17 | — | — | WO | disclosed |