Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | GSK3A | P49840 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 3/20 | 0.34 |
| ▸ | CDK4 | P11802 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CDK7 | P50613 | 3/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CCNH | P51946 | 2/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550010 | 0.88 | ADORA1 (0.45) | ADORA1GSK3BGSK3AJAK3GBA1 | |
| SCHEMBL3525368 | 0.87 | ADORA1 (0.44) | ADORA1GSK3BGSK3AJAK3GBA1 | |
| SCHEMBL5550083 | 0.81 | ADORA1 (0.53) | ADORA1GSK3BGSK3AGBA1MAPK1 | |
| SCHEMBL5543633 | 0.80 | ADORA1 (0.50) | ADORA1GSK3BGSK3AJAK3L3MBTL1 | |
| SCHEMBL5543503 | 0.78 | ADORA1 (0.50) | ADORA1GSK3BGSK3AJAK3GBA1 | |
| SCHEMBL5549322 | 0.78 | ADORA1 (0.45) | ADORA1GSK3BGSK3AJAK3L3MBTL1 | |
| SCHEMBL5548882 | 0.78 | ADORA1 (0.45) | ADORA1GSK3BGSK3AJAK3GBA1 | |
| SCHEMBL5549074 | 0.77 | ADORA1 (0.49) | ADORA1GSK3BGSK3AJAK3GBA1 | |
| SCHEMBL5545500 | 0.76 | ADORA1 (0.49) | ADORA1GSK3BGSK3AJAK3GBA1 | |
| SCHEMBL3525903 | 0.76 | ADORA1 (0.50) | ADORA1GSK3BGSK3AJAK3GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1678180-A1 | SUBSTITUTED 2H- 1,2,4 TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | Pfizer Products Incorporated (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005035532-A1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS GSK-3 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-04-21 | — | — | WO | disclosed |