Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13598830 | 0.85 | HCAR3 (0.61) | KAT2BKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9395746 | 0.84 | KMT2A (0.53) | KAT2BKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL16722175 | 0.84 | KMT2A (0.53) | KAT2BKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL30274042 | 0.81 | HCAR3 (0.55) | KAT2BKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL103504 | 0.81 | HCAR3 (0.55) | KAT2BKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL28179606 | 0.80 | HCAR3 (0.54) | KAT2BKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14407545 | 0.79 | ALDH1A1 (0.56) | KMT2AMEN1SMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL29744939 | 0.79 | HCAR3 (0.45) | KAT2BKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL30128459 | 0.78 | KMT2A (0.53) | KMT2AMEN1SMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL128849 | 0.78 | KMT2A (0.53) | KMT2AMEN1SMN1; SMN2L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711184-B1 | (3-OXO-3,4-DIHYDRO-QUINOXALIN-2-YL-AMINO)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN PHOSPHORYLASE INHIBITORS FOR THE TREATMENT OF DIABETES AND OBESITY | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-18 | — | — | EP | disclosed |